Karima Mansour Ali , Manal Hosny Mostafa, Olfat Shaker And Engy Ahmed,

ABSTRACT
Background: Among The Most Common Forms Of Periodontal Disease Is Chronic Periodontitis. Most Tissue Damage Found In Patients With Periodontitis Result From An Exaggerated Host Immune Response To Bacterial Challenges Which Results In The Secretion Of Proinflammatory Cytokines That Results In Destruction Of Periodontal Tissues. The Levels Of Prostaglandin E2 (PGE2) In Gingival Crevicular Fluid (GCF) Have Been Reported To Correlate Positively With Periodontal Inflammation. Nutrition Plays A Great Role In Improving The Person Quality Of Life, For Example Omega -3 PUFA Has A Well-established Anti-inflammatory Role In Periodontal Disease. Adequate Dietary Intake Of Omega-3 Polyunsaturated Fatty Acids (n-3 PUFAs) Resulted In Increases Tissue Concentration Of The Types Of Fatty Acids(e.g., Eicosapentaenoic Acid And Docosahexaenoic Acid) That Downregulate Inflammation, Omega-3(n-3)PUFA Have Multiple Actions By Which They Can Affect Cell And Tissue Behavior To Perform Their Physiological Actions. Aim Of Study: This Study Was Undertaken To Evaluate The Effects Of Omega-3 Fatty Acids Supplementation After Modified Widman Periodontal Flap Surgery On Clinical Parameters And GCF Levels Of Prostaglandin E2 (PGE2). Methods: The Present Study Had Included 40 Subjects (10 Healthy Volunteers And 30 Patients With Moderate To Advanced Chronic Periodontitis). Group I (Test Group): 15 Patients With Moderate To Advanced Chronic Periodontitis Treated With Modified Widman Flap Adjuncted With Omega 3 FA 1200 Mg Taken Orally Daily For 4 Months After MWF Surgery, Group II (Control Group): 15 Patients With Moderate To Advanced Chronic Periodontitis Treated With Modified Widman Flap Only.Evaluation Of Clinical Periodontal Parameters Were Recorded For Full Mouth And At The Most Periodontally Affected Sites (PPD � 5mm) At Baseline And 2 And 4 Months After Periodontal Surgery.

Results: Results Of The Present Study Indicate That Daily Dietary Supplementation Of Omega 3 PUFA As An Adjunct To Surgical Periodontal Therapy Has Resulted In Improvement In Clinical Outcomes Of Pocket Depth(PD) And Clinical Attachment Level (CAL), And Significant Reduction Of GCF Markers Of Bone Resorption And Inflammation (PGE2)indicating That Omega 3 Protect Against Bone Resorption.